Arthritis Website

I'm looking to improve the look and feel of the website and open it up for different ad formats. I have a pretty good idea of what I want and have described in detail.

http://www.arthritisinsight.com

Content Page Design
Begin Horizontal Ad Bar
    Ad bar720 x 90
End Horizontal Ad bar
Begin Horizontal Top navigation bar
    Centered Text Links: About Us - Contact Us  - Site Map
    Google Search Box - in middle of nav bar.
    Home -
    Medical Info -
    Conditions -
    Medications -
    Living with Arthritis-
    Resources -
    Community -

End Horizontal Top Nav Bar
Begin 3 Vertical Columns
    Column 1-
    Side Navigation bar 200x 700
    Column2 -
    Center information for content
    Column 3 - Ad and additional content squares
        Square 1-
        right navigation bar is 300 x 250 for 1 ad
        Square 2 (under square 1) -
        related information box that is 300 x250
End of 3 Vertical Columns

Begin of Lower Ad Bar
    728 x 90 ad space
End of Lower Ad bar
Begin Site Links:
Text Links:  Home  |  Contact Us  |  Advertise  |  Subscribe  |  Privacy Policy  |  Glossary  |  Site map  
End Site Links

Begin of Bottom Search Engine Follow bar
    approximately 200 pixels high
    Links to replace drop down links so search engine can follow
    
End of Bottom Search Engine Follow bar

Template 1 - Front Page Design
Begin Horizontal Ad Bar
    Ad bar720 x 90
End Horizontal Ad bar
Begin Horizontal Top navigation bar
    Centered Text Links: About Us - Contact Us  - Site Map
    Google Search Box - in middle of nav bar.
    Home -
    Medical Info -
    Conditions -
    Medications -
    Living with Arthritis-
    Resources -
    Community -

End Horizontal Top Nav Bar
Begin Horizontal Rectangle that is approx 200 pixels high and 100% page container width.

    Column 1- 60% width
    
    rounded rectangle with flash image that will animate between the site dropdowns - leave blank for
    design puposes.
    Column 2 -40% width
    
        300 x 250 ad space.

End of Horizontal Rectangle

Begin Horizontal Rectangle that is approx 400 pixels high and 100% page containter width
Row 1
    Begin Rounded 50% width Rectangle
        Title:News and Headlines
    End Rounded Rectangle
    Begin Rounded 50% width Rectangle
        Title:Community Postings
    End Rounded Rectangle
Row 2
    Begin Rounded 30% width Rectangle
        Title: Subscribe to our newsletter
        Include name and email and a form
    End Rounded Rectangle
    Begin Rounded %30 width Rectangle
        Title: New here?
        
    End Rounded Rectangle
    
    Begin Rounded 30% width Rectangle
        Title: Question of the Week
    End Rounded Rectangle
    
        
End of Horizontal Rectangle
Begin of Lower Ad Bar
    728 x 90 ad space
End of Lower Ad bar
Begin Site Links:
Text Links:  Home  |  Contact Us  |  Advertise  |  Subscribe  |  Privacy Policy  |  Glossary  |  Site map  
End Site Links

- Item 1.. This design will have to appeal to pharma advertisers so the look must be clean since advertisers won't advertise if not spotless.

- Item 1...I don't want any low quality images or design since I'm seeking advertising from pharma companies.